Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084729 | 0.95 | HSP90B1 (0.34) | HSP90B1TRAP1LMNA | |
| SCHEMBL6973857 | 0.95 | LMNA (0.33) | THRBHSP90B1TRAP1FLT1KDR | |
| SCHEMBL6973396 | 0.93 | PIM1 (0.34) | HSP90B1TRAP1 | |
| SCHEMBL6964425 | 0.92 | THRB (0.32) | THRBHSP90B1TRAP1FLT1KDR | |
| SCHEMBL6960609 | 0.92 | MAPT (0.37) | LMNAMAPT | |
| SCHEMBL6973057 | 0.91 | LMNA (0.34) | HSP90B1TRAP1LMNA | |
| SCHEMBL7080228 | 0.90 | MEN1 (0.34) | CDK5CDK5R1RXFP1 | |
| SCHEMBL6967720 | 0.89 | GLA (0.32) | HSP90B1TRAP1 | |
| SCHEMBL6971680 | 0.88 | PIM1 (0.33) | HSP90B1TRAP1LMNA | |
| SCHEMBL6969197 | 0.87 | HSP90B1 (0.32) | HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |