Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.72 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.72 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.72 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154047 | 0.84 | TGFBR1 (0.89) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL373802 | 0.84 | TGFBR1 (1.00) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4078016 | 0.83 | TGFBR1 (0.73) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4082163 | 0.80 | MAPK14 (0.67) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4085338 | 0.80 | TGFBR1 (0.74) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4084904 | 0.76 | TGFBR1 (0.84) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4086169 | 0.75 | MAPK14 (0.62) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13217780 | 0.75 | TGFBR1 (0.59) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL28825919 | 0.73 | TGFBR1 (0.82) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6181382 | 0.72 | TGFBR1 (0.78) | TGFBR1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169317-B1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6465493-B1 | SUCH AS 4-(4-(4-FLUOROPHENYL)-5-(2-PYRIDYL)-1-HYDROXY-1H-IMIDAZOL-2-YL)BENZONITRILE; ALK5 MEDIATED DISEASES SUCH AS ARTHRITIS, OSTEOPOROSIS, KIDNEY AND RENAL DISEASES, CONGES-TIVE HEART FAILURE, ULCERS, DIABETIC NEPHROPATHY | SMITHKLINE BEECHAM CORPORATION | 2002-10-15 | — | — | US | disclosed |
| EP-1169317-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061576-A1 | TRIARYLIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-19 | — | — | WO | disclosed |