Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976892 | 0.88 | ADRA2A (0.58) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8382829 | 0.88 | ADRA2A (0.58) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL6980394 | 0.87 | NPC1 (0.45) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8382610 | 0.87 | NPC1 (0.45) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8386689 | 0.84 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL6977805 | 0.84 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8383034 | 0.84 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL6981556 | 0.84 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL6980314 | 0.83 | CACNA1I (0.53) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8386721 | 0.83 | CACNA1I (0.53) | ADRA1DADRA1AADRA1BDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | claimed |
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | disclosed |