Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 9/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.53 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.53 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.53 |
| ▸ | CHRNG | P07510 | 1/20 | 0.53 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.53 |
| ▸ | CHRND | Q07001 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961453 | 0.90 | CHRNA3 (0.55) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| Fumaric Acid SCHEMBL6972261 | 0.83 | CHRNA3 (0.54) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| SCHEMBL6960347 | 0.80 | CHRNA3 (0.55) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| SCHEMBL6814162 | 0.80 | CHRNA3 (0.55) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| SCHEMBL13388063 | 0.79 | CHRNA3 (0.70) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| SCHEMBL6813849 | 0.79 | CHRNA3 (0.52) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| SCHEMBL6966231 | 0.79 | CHRNA3 (0.54) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| Fumaric Acid SCHEMBL6961573 | 0.77 | CHRNB4 (0.59) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| SCHEMBL6813669 | 0.76 | CHRNA3 (0.64) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 | |
| SCHEMBL6818785 | 0.76 | CHRNA3 (0.58) | CHRNA3CHRNB2CHRNA1CHRNB4CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739342-B1 | PYRIDINE MODULATORS OF ACETYLCHOLINE RECEPTORS | MERCK & CO INC (US) | 2003-08-27 | — | — | EP | disclosed |