Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978354 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1F2RL3 | |
| SCHEMBL6976230 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1F2RL3 | |
| SCHEMBL6976132 | 0.84 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL6978032 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL6976876 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL6973119 | 0.76 | P2RY6 (0.40) | PTGS2PTGS1NPSR1MAPTP2RY6 | |
| SCHEMBL4032238 | 0.75 | PTGS1 (0.74) | PTGS2PTGS1NPSR1MAPT | |
| SCHEMBL6973228 | 0.72 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL25150243 | 0.72 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL9273738 | 0.72 | PTGS2 (0.72) | PTGS2PTGS1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006114-B1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | GRELAN PHARMACEUTICAL CO (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6136831-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL AGENTS, ENZYME INHIBITORS | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-1006114-A1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | Grelan Pharmaceutical Co., Ltd. (JP) | 2000-06-07 | — | — | EP | disclosed |