Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014357 | 0.89 | NPC1 (0.51) | NPC1RAB9ACYP1A2PDK1VCAM1 | |
| SCHEMBL7827901 | 0.86 | CYP1A2 (0.54) | NPC1RAB9ACYP1A2PDK1VCAM1 | |
| SCHEMBL9452749 | 0.84 | CYP1A2 (0.69) | NPC1RAB9ACYP1A2PDK1VCAM1 | |
| SCHEMBL11329796 | 0.84 | NPC1 (0.52) | NPC1RAB9ACYP1A2PDK1VCAM1 | |
| SCHEMBL442788 | 0.84 | CYP1A2 (0.69) | NPC1RAB9ACYP1A2PDK1VCAM1 | |
| SCHEMBL6973315 | 0.84 | NPC1 (0.50) | NPC1RAB9ACYP1A2TSHRMAPK1 | |
| SCHEMBL357928 | 0.83 | PDK1 (0.55) | CYP1A2PDK1VCAM1TSHRMAPK1 | |
| SCHEMBL9726169 | 0.83 | NPC1 (0.51) | NPC1RAB9ACYP1A2PDK1VCAM1 | |
| Hydrochloric Acid SCHEMBL11329805 | 0.83 | CYP1A2 (0.67) | NPC1RAB9ACYP1A2PDK1VCAM1 | |
| SCHEMBL28263084 | 0.83 | NPC1 (0.51) | NPC1RAB9ACYP1A2PDK1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807631-B1 | Tricyclic compounds having fungicidal activity, their preparation and their use | SANKYO CO (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-5981752-A | Tricyclic compounds having fungicidal activity, their preparation and their use | SANKYO COMPANY, LIMITED (JP) | 1999-11-09 | — | — | US | disclosed |
| US-5773618-A | PYRROLOQUINOLINONE DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1998-06-30 | — | — | US | disclosed |
| EP-0807631-A1 | Tricyclic compounds having fungicidal activity, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1997-11-19 | — | — | EP | disclosed |