Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.46 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.46 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992133 | 0.86 | PDK1 (0.50) | PDK1MAPK1TSHRVCAM1ALDH1A1 | |
| SCHEMBL365653 | 0.86 | USP7 (0.51) | PDK1MAPK1TSHRVCAM1ALDH1A1 | |
| SCHEMBL2949639 | 0.85 | TSHR (0.60) | PDK1MAPK1TSHRVCAM1ALDH1A1 | |
| SCHEMBL67686 | 0.85 | ALDH1A1 (0.58) | MAPK1TSHRVCAM1ALDH1A1POLB | |
| SCHEMBL6973314 | 0.83 | NPC1 (0.50) | PDK1MAPK1TSHRVCAM1ALDH1A1 | |
| SCHEMBL2112011 | 0.83 | MAPK1 (0.53) | MAPK1TSHRVCAM1ALDH1A1POLB | |
| SCHEMBL29495064 | 0.83 | MAPK1 (0.53) | MAPK1TSHRVCAM1ALDH1A1POLB | |
| SCHEMBL67536 | 0.83 | MAPK1 (0.53) | MAPK1TSHRVCAM1ALDH1A1NPSR1 | |
| SCHEMBL28859046 | 0.83 | MAPK1 (0.53) | MAPK1TSHRVCAM1ALDH1A1POLB | |
| SCHEMBL1509585 | 0.83 | MAPK1 (0.53) | MAPK1TSHRVCAM1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641887-B | Thiazole derivatives useful as mutant IDH1 inhibitors for the treatment of cancer | 美国政府健康及人类服务部 | 2022-09-20 | — | — | CN | disclosed |
| EP-3237385-B1 | MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER | US HEALTH (US) | 2021-11-24 | — | — | EP | disclosed |
| CN-107428690-B | Mutant IDH1 inhibitors useful for the treatment of cancer | 美国政府健康及人类服务部 | 2021-04-13 | — | — | CN | disclosed |
| EP-3475276-B1 | THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER | US HEALTH (US) | 2021-03-31 | — | — | EP | disclosed |
| US-10836759-B2 | Thiazole derivatives useful as mutant IDH1 inhibitors for treating cancer | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2020-11-17 | — | — | US | disclosed |
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-07-07 | — | — | US | disclosed |
| US-10479778-B2 | Substituted pyrroles active as kinases inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-11-19 | — | — | US | disclosed |
| US-10479779-B2 | Substituted pyrroles active as kinases inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-11-19 | — | — | US | disclosed |
| US-20190241551-A1 | THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2019-08-08 | — | — | US | disclosed |
| CN-110003219-A | Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator | 弗·哈夫曼-拉罗切有限公司 | 2019-07-12 | — | — | CN | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
| US-7576117-B1 | Cyclic amine CCR3 antagonist | TEIJIN LIMITED (JP) | 2009-08-18 | — | — | US | disclosed |
| US-7576117-B1 | Cyclic amine CCR3 antagonist | TEIJIN LIMITED (JP) | 2009-08-18 | — | — | US | disclosed |
| EP-1617807-A4 | SUBSTITUTED 1,4-DIAZEPINES AND USES THEREOF | ORTHO MCNEIL PHARM INC (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1712235-A2 | Combinational therapy involving a small molecule inhibitor of the MDM2: P53 interaction | Ortho-McNeil Pharmaceutical, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| US-7115598-B2 | Substituted 1,4-diazepines and uses thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1617807-A2 | SUBSTITUTED 1,4-DIAZEPINES AND USES THEREOF | Ortho-McNeil Pharmaceuticals, Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004096134-A2 | SUBSTITUTED 1,4-DIAZEPINES AND USES THEREOF | ORTHO-MCNEIL PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |
| US-20040220179-A1 | Substituted 1,4-diazepines and uses thereof | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836759-B2 | Thiazole derivatives useful as mutant IDH1 inhibitors for treating cancer | IDH1, IDH2, IDH3B | PDK1 751/4885MAPK1 1175/4885TSHR 1897/4885 |
| US-20190241551-A1 | THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER | IDH1, IDH2, IDH3B | PDK1 751/4885MAPK1 1175/4885TSHR 1897/4885 |
| US-10479779-B2 | Substituted pyrroles active as kinases inhibitors | JAK2, JAK1, JAK3 | PDK1 110/4885MAPK1 242/4885TSHR 3959/4885 |
| US-20040220179-A1 | Substituted 1,4-diazepines and uses thereof | TP53, MDM2, HRH2 | PDK1 1577/4885MAPK1 3747/4885TSHR 1587/4885 |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | PDK1 576/4885MAPK1 313/4885TSHR 2294/4885 |
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | IDH1, IDH3B, IDH3A | PDK1 94/4885MAPK1 1759/4885TSHR 4167/4885 |
| US-10479778-B2 | Substituted pyrroles active as kinases inhibitors | JAK2, JAK1, JAK3 | PDK1 110/4885MAPK1 242/4885TSHR 3959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.