Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118198 | 0.80 | KDM4E (0.50) | SIGMAR1TSHRRECQLSMN1; SMN2HTR1D | |
| SCHEMBL31459863 | 0.79 | FUCA1 (0.47) | SIGMAR1DRD4ACHE | |
| SCHEMBL5534419 | 0.79 | FUCA1 (0.47) | SIGMAR1DRD4ACHE | |
| SCHEMBL15112286 | 0.78 | HTR1D (0.54) | SIGMAR1TSHRRECQLSMN1; SMN2TRPV6 | |
| SCHEMBL4797625 | 0.76 | SIGMAR1 (0.69) | SIGMAR1TSHRRECQLSMN1; SMN2TRPV6 | |
| SCHEMBL4275700 | 0.76 | SIGMAR1 (0.58) | SIGMAR1TSHRRECQLSMN1; SMN2TRPV6 | |
| SCHEMBL3709310 | 0.75 | RECQL (0.70) | SIGMAR1TSHRRECQLSMN1; SMN2TRPV6 | |
| SCHEMBL22169537 | 0.74 | RECQL (0.48) | SIGMAR1TSHRRECQLSMN1; SMN2TRPV6 | |
| Hydrochloric Acid SCHEMBL3706762 | 0.74 | RECQL (0.68) | SIGMAR1TSHRRECQLSMN1; SMN2TRPV6 | |
| SCHEMBL13943667 | 0.74 | SIGMAR1 (0.64) | SIGMAR1TSHRRECQLSMN1; SMN2TRPV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030176445-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. | 2003-09-18 | — | — | US | disclosed |
| EP-1106615-B1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| US-20020042421-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | OKUMURA YOSHIYUKI (JP) | 2002-04-11 | — | — | US | disclosed |
| EP-1106615-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176445-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, HRH4 | SIGMAR1 278/4885TSHR 2853/4885RECQL 3084/4885 |
| US-20020042421-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, HRH4 | SIGMAR1 297/4885TSHR 3440/4885RECQL 3772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.