Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967295 | 0.90 | CCR3 (0.42) | SIGMAR1CCR3KDM4EALDH1A1C5AR1 | |
| SCHEMBL6977411 | 0.87 | CCR3 (0.41) | SIGMAR1CCR3KDM4EALDH1A1SSTR5 | |
| SCHEMBL6975673 | 0.87 | CYP2D6 (0.45) | CCR3KDM4EALDH1A1DRD4DRD2 | |
| SCHEMBL6976709 | 0.86 | CCR3 (0.45) | SIGMAR1CCR3KDM4ESSTR5DRD4 | |
| SCHEMBL6969244 | 0.85 | CHKA (0.45) | SIGMAR1KDM4EALDH1A1DRD4DRD2 | |
| SCHEMBL6968225 | 0.83 | SMN1; SMN2 (0.42) | SIGMAR1CCR3ALDH1A1SSTR5DRD4 | |
| SCHEMBL6968412 | 0.83 | OPRL1 (0.39) | SIGMAR1CCR3SSTR5DRD4DRD2 | |
| SCHEMBL6976705 | 0.82 | CHRM4 (0.42) | CCR3ALDH1A1CXCR3 | |
| SCHEMBL6966441 | 0.81 | OPRL1 (0.38) | CCR3C5AR1SSTR5DRD4DRD2 | |
| SCHEMBL6967328 | 0.81 | CCR3 (0.36) | SIGMAR1CCR3ALDH1A1SSTR5DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |