Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967295 | 0.93 | CCR3 (0.42) | KDM4EALDH1A1POLBSIGMAR1DRD2 | |
| SCHEMBL6977411 | 0.87 | CCR3 (0.41) | KDM4EALDH1A1SIGMAR1DRD2DRD4 | |
| SCHEMBL6973584 | 0.85 | SIGMAR1 (0.40) | KDM4EALDH1A1SIGMAR1DRD2DRD4 | |
| SCHEMBL6975673 | 0.84 | CYP2D6 (0.45) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL6976709 | 0.84 | CCR3 (0.45) | KDM4EPOLBSIGMAR1DRD2DRD4 | |
| SCHEMBL6967328 | 0.82 | CCR3 (0.36) | ALDH1A1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL6967508 | 0.81 | DPP7 (0.41) | KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL6976705 | 0.80 | CHRM4 (0.42) | ALDH1A1 | |
| SCHEMBL6968225 | 0.77 | SMN1; SMN2 (0.42) | ALDH1A1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL6968412 | 0.77 | OPRL1 (0.39) | SIGMAR1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |