Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973584 | 0.87 | SIGMAR1 (0.40) | KDM4EALDH1A1DRD4GPR183DRD2 | |
| SCHEMBL6967295 | 0.86 | CCR3 (0.42) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL6977411 | 0.86 | CCR3 (0.41) | MEN1KMT2AKDM4EALDH1A1DRD4 | |
| SCHEMBL6976709 | 0.85 | CCR3 (0.45) | CYP2D6MEN1KMT2AKDM4EDRD4 | |
| SCHEMBL6969244 | 0.84 | CHKA (0.45) | KDM4EALDH1A1DRD4DRD2DRD3 | |
| SCHEMBL6968412 | 0.81 | OPRL1 (0.39) | FAAHDRD4GPR183DRD2DRD3 | |
| SCHEMBL6976705 | 0.81 | CHRM4 (0.42) | MEN1KMT2AALDH1A1CCR3 | |
| SCHEMBL6966441 | 0.80 | OPRL1 (0.38) | FAAHDRD4DRD2DRD3CCR3 | |
| SCHEMBL6967328 | 0.80 | CCR3 (0.36) | CYP2D6MEN1KMT2AALDH1A1DRD4 | |
| SCHEMBL6968225 | 0.78 | SMN1; SMN2 (0.42) | ALDH1A1DRD4DRD2DRD3PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |