Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977071 | 0.87 | HTR6 (0.44) | HTR6CYP3A4CYP2D6TP53 | |
| SCHEMBL6977129 | 0.87 | PPARG (0.43) | HTR6CYP3A4CYP2D6MAOB | |
| SCHEMBL6977903 | 0.85 | AR (0.46) | HTR6CNR2ACHECNR1MAOB | |
| SCHEMBL6966090 | 0.84 | HTR6 (0.44) | HTR6CYP3A4CYP2D6CA12CA1 | |
| SCHEMBL6961975 | 0.81 | PTGDR (0.42) | HTR6CYP3A4CYP2D6PTGDRPTGDR2 | |
| SCHEMBL6965738 | 0.80 | MAPT (0.44) | HTR6KDM4EALDH1A1TP53 | |
| SCHEMBL6977906 | 0.79 | CNR2 (0.40) | HTR6CNR2ACHECNR1MAOB | |
| SCHEMBL6967275 | 0.79 | HTR6 (0.42) | HTR6CYP3A4CYP2D6KDM4EPTGDR | |
| SCHEMBL6966615 | 0.79 | KMT2A (0.43) | HTR6CYP3A4CYP2D6KDM4EPTGDR | |
| SCHEMBL6971624 | 0.78 | HTR6 (0.41) | HTR6CYP3A4CYP2D6KDM4EPTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |