Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965738 | 0.93 | MAPT (0.44) | HTR6TP53GPR84HTR1ADRD2 | |
| SCHEMBL6973700 | 0.87 | HTR6 (0.45) | HTR6CYP3A4CYP2D6TP53 | |
| SCHEMBL6977129 | 0.81 | PPARG (0.43) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL6970750 | 0.80 | MAPT (0.47) | HTR6CYP3A4TP53SMN1; SMN2 | |
| SCHEMBL6966090 | 0.80 | HTR6 (0.44) | HTR6CYP3A4CYP2D6TP53 | |
| SCHEMBL6977499 | 0.79 | MAPT (0.55) | HTR6CYP3A4TP53SMN1; SMN2 | |
| SCHEMBL6967417 | 0.78 | HTR6 (0.41) | HTR6SMN1; SMN2 | |
| SCHEMBL6971073 | 0.78 | ALDH1A1 (0.49) | HTR6CYP3A4CYP2D6RAB9ASMN1; SMN2 | |
| SCHEMBL6977903 | 0.77 | AR (0.46) | HTR6TP53HTR2ADRD2HTR7 | |
| SCHEMBL6967275 | 0.77 | HTR6 (0.42) | HTR6CYP3A4CYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |