Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965201 | 0.86 | KMT2A (0.55) | POLBKMT2AMEN1ALDH1A1SIRT3 | |
| SCHEMBL24377986 | 0.86 | KMT2A (0.55) | POLBKMT2AMEN1ALDH1A1SIRT3 | |
| SCHEMBL29516078 | 0.86 | KMT2A (0.55) | POLBKMT2AMEN1ALDH1A1SIRT3 | |
| SCHEMBL12695925 | 0.86 | SIRT3 (0.58) | POLBKMT2AMEN1ALDH1A1SIRT3 | |
| SCHEMBL925973 | 0.84 | POLB (0.49) | POLBKMT2AMEN1ALDH1A1SIRT3 | |
| SCHEMBL7820037 | 0.84 | POLB (0.53) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8564035 | 0.83 | P2RX4 (0.49) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8564037 | 0.83 | P2RX4 (0.49) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8564040 | 0.83 | P2RX4 (0.49) | POLBKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7817475 | 0.81 | SIRT1 (0.50) | POLBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140925-B1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | WYETH CORP (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6313114-B1 | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |
| EP-1140925-A1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040580-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINYL-METHYL[3-(1H-INDOL-3-YL)-ALKYL]-AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |