Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 14/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820037 | 0.85 | POLB (0.53) | SIRT1SIRT2POLBALDH1A1KMT2A | |
| SCHEMBL11567520 | 0.85 | SIRT1 (0.69) | SIRT1SIRT2POLB | |
| SCHEMBL7829862 | 0.84 | SIRT1 (0.49) | SIRT1SIRT2POLBALDH1A1KMT2A | |
| SCHEMBL10854878 | 0.83 | ALDH1A1 (0.56) | SIRT1SIRT2POLBNISCHALDH1A1 | |
| SCHEMBL10855360 | 0.83 | ALDH1A1 (0.52) | SIRT1SIRT2POLBALDH1A1KMT2A | |
| SCHEMBL7819461 | 0.82 | SIRT1 (0.47) | SIRT1SIRT2POLBALDH1A1KMT2A | |
| SCHEMBL12610719 | 0.81 | SIRT1 (0.58) | SIRT1SIRT2POLBKMT2A | |
| SCHEMBL6973740 | 0.81 | POLB (0.54) | POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL11567525 | 0.79 | SIRT1 (0.47) | SIRT1SIRT2POLB | |
| SCHEMBL16758497 | 0.78 | SIRT1 (0.52) | SIRT1SIRT2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894796-B1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6057317-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 2000-05-02 | — | — | US | disclosed |
| EP-0894796-A1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |