Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | SELL | P14151 | 2/20 | 0.40 |
| ▸ | SELP | P16109 | 2/20 | 0.40 |
| ▸ | SELE | P16581 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7733874 | 0.84 | HDAC3 (0.49) | KMT2AMEN1ALDH1A1LMNAKDM4E | |
| SCHEMBL6969104 | 0.83 | GAA (0.45) | KMT2AMEN1ALDH1A1LMNAKDM4E | |
| SCHEMBL6960412 | 0.81 | GAA (0.43) | KMT2AMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL6962364 | 0.79 | MEN1 (0.50) | KMT2AMEN1ALDH1A1LMNAKDM4E | |
| SCHEMBL5741936 | 0.77 | GAA (0.55) | KMT2AMEN1ALDH1A1LMNAKDM4E | |
| SCHEMBL1853620 | 0.75 | MEN1 (0.62) | KMT2AMEN1ALDH1A1LMNAKDM4E | |
| SCHEMBL11914171 | 0.75 | NAMPT (0.51) | KMT2AMEN1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL8078098 | 0.75 | GAA (0.67) | KMT2AMEN1ALDH1A1LMNAKDM4E | |
| SCHEMBL14586752 | 0.75 | GAA (0.57) | KMT2AMEN1ALDH1A1LMNAKDM4E | |
| SCHEMBL785309 | 0.74 | NLRP3 (0.58) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785927-B1 | NOVEL BENZOXAZOLES | EURO CELTIQUE SA (LU) | 2003-08-27 | — | — | EP | disclosed |
| US-6372770-B1 | TREATING A MAMMAL SUFFERING FROM A DISEASE STATE SELECTED FROM THE GROUP CONSISTING OF ASTHMA, ALLERGIES, INFLAMMATION, DEPRESSION, DEMENTIA, ATOPIC DISEASES, RHINITIS AND DISEASE STATES ASSOCIATED WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF | EURO-CELTIQUE, S.A. | 2002-04-16 | — | — | US | disclosed |
| US-6365606-B1 | TREATMENT OF DISEASES WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF CYTOKINES; SIDE EFFECT REDUCTION; ISOINDOLES; BRONCHODILATOR; ANTI-INFLAMMATORY AGENT | EURO-CELTIQUE, S.A. (LU) | 2002-04-02 | — | — | US | disclosed |
| EP-1160247-A1 | 6,5-Fused aromatic ring systems having enhanced phosphodiesterae IV inhibitory activity | Euro-Celtique S.A. (LU) | 2001-12-05 | — | — | EP | disclosed |
| US-6075016-A | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity | EURO-CELTIQUE S.A. (LU) | 2000-06-13 | — | — | US | disclosed |
| EP-0785927-A4 | NOVEL BENZOXAZOLES | EURO CELTIQUE SA (LU) | 1997-12-29 | — | — | EP | disclosed |
| EP-0785927-A1 | NOVEL BENZOXAZOLES | Euroceltique S.A. (LU) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011917-A1 | NOVEL BENZOXAZOLES | EURO-CELTIQUE, S.A. (LU) | 1996-04-25 | — | — | WO | disclosed |