SCHEMBL6973932

SCHEMBL6973932

CC(C)c1nc(CN)n(C)c1Sc1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.36
SLC6A4 P31645 1/20 0.36
LOXL2 Q9Y4K0 2/20 0.34
ALDH1A1 P00352 2/20 0.33
HPGD P15428 1/20 0.33
MAOA P21397 3/20 0.33
MAOB P27338 3/20 0.33
DHFR P00374 2/20 0.33
CXCL12 P48061 1/20 0.31
CHRNA7 P36544 1/20 0.31
POLB P06746 1/20 0.31
KDM4E B2RXH2 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
PTPN1 P18031 1/20 0.31
CDC25A P30304 1/20 0.31
CDC25B P30305 1/20 0.31
TAAR1 Q96RJ0 1/20 0.30
PTGDR2 Q9Y5Y4 1/20 0.30
HRH4 Q9H3N8 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6967632 0.86 SMN1; SMN2 (0.36) SMN1; SMN2SLC6A4ALDH1A1HPGDMAOA
SCHEMBL6968786 0.86 SMN1; SMN2 (0.45) SMN1; SMN2SLC6A4ALDH1A1HPGDMAOA
SCHEMBL6973797 0.84 MAOA (0.38) LOXL2ALDH1A1MAOAMAOB
SCHEMBL6961416 0.84 MEN1 (0.39) SLC6A4ALDH1A1HPGDMAOAMAOB
Hydrochloric Acid SCHEMBL6967801 0.83 MEN1 (0.38) SLC6A4ALDH1A1HPGDMAOAMAOB
SCHEMBL6974087 0.83 SMN1; SMN2 (0.35) SMN1; SMN2SLC6A4ALDH1A1HPGDMAOA
SCHEMBL6967197 0.83 SLC6A4 (0.34) SMN1; SMN2SLC6A4ALDH1A1HPGDMAOA
SCHEMBL6974787 0.83 SMN1; SMN2 (0.35) SMN1; SMN2SLC6A4ALDH1A1HPGDMAOA
SCHEMBL6960385 0.83 SMN1; SMN2 (0.35) SMN1; SMN2SLC6A4ALDH1A1HPGDMAOA
SCHEMBL6962737 0.83 SMN1; SMN2 (0.40) SMN1; SMN2SLC6A4ALDH1A1HPGDMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed