SCHEMBL6973978

SCHEMBL6973978

COc1ccc2c3ccccc3n3cc(Cc4cccnc4)c(=O)c1c23

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.39
CNR2 P34972 1/20 0.39
KDM4E B2RXH2 3/20 0.39
ALDH1A1 P00352 3/20 0.36
MAPK1 P28482 1/20 0.36
PDE10A Q9Y233 1/20 0.36
LMNA P02545 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
USP2 O75604 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KMT2A Q03164 1/20 0.36
TSHR P16473 2/20 0.36
HTT P42858 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP3A4 P08684 2/20 0.36
CYP2C9 P11712 1/20 0.36
MAPT P10636 1/20 0.35
PTPN1 P18031 1/20 0.35
GABRA1 P14867 1/20 0.35
GABRA5 P31644 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6982514 0.92 CNR1 (0.39) CNR1CNR2KDM4EALDH1A1MAPK1
SCHEMBL6979540 0.83 CNR1 (0.39) CNR1CNR2KDM4EALDH1A1MAPK1
SCHEMBL6979014 0.81 GABRA1 (0.41) CNR1CNR2KDM4EALDH1A1KMT2A
SCHEMBL7670714 0.78 KCNH2 (0.39) KDM4ELMNAL3MBTL1TSHRHTT
SCHEMBL6977266 0.78 CNR1 (0.42) CNR1CNR2KDM4EALDH1A1MAPK1
SCHEMBL6981815 0.78 GABRA1 (0.46) KDM4EALDH1A1KMT2ACYP2C9MAPT
SCHEMBL7666493 0.77 GABRA1 (0.40) CNR1CNR2KDM4ELMNATSHR
SCHEMBL6976958 0.75 GUSB (0.37) KDM4ELMNAKMT2ATSHRHTT
SCHEMBL6984153 0.75 ADORA2A (0.38) KDM4ELMNATSHRHTTCYP1A2
SCHEMBL8153648 0.75 VKORC1 (0.40) CNR1CNR2KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed