Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 10/20 | 0.53 |
| ▸ | APOB | P04114 | 9/20 | 0.53 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974831 | 0.87 | TMPRSS2 (0.42) | MTTPAPOBNPC1RAB9ATMPRSS2 | |
| SCHEMBL6969388 | 0.86 | MTTP (0.51) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6975568 | 0.85 | MTTP (0.51) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6966884 | 0.85 | APOB (0.61) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6965797 | 0.85 | MTTP (0.58) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL7626403 | 0.84 | MTTP (0.54) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6973387 | 0.84 | MTTP (0.56) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6973467 | 0.83 | MTTP (0.55) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6973765 | 0.83 | APOB (0.58) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6963061 | 0.83 | MTTP (0.63) | MTTPAPOBSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | claimed |