Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 13/20 | 0.51 |
| ▸ | APOB | P04114 | 10/20 | 0.51 |
| ▸ | SMO | Q99835 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963054 | 0.87 | PAX8 (0.41) | MTTPAPOBSMOGAAMAPT | |
| SCHEMBL6974436 | 0.86 | MTTP (0.53) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8207409 | 0.85 | MTTP (0.51) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6975568 | 0.85 | MTTP (0.51) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6973387 | 0.85 | MTTP (0.56) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6966884 | 0.84 | APOB (0.61) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6965797 | 0.84 | MTTP (0.58) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL6973467 | 0.84 | MTTP (0.55) | MTTPAPOBSMOKDM4EGAA | |
| SCHEMBL8470465 | 0.84 | POLB (0.41) | MTTPKDM4EGAAALDH1A1LMNA | |
| SCHEMBL7626403 | 0.83 | MTTP (0.54) | MTTPAPOBSMOKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1099442-A2 | Methods of administering apo B-secretion/MTP inhibitors | Pfizer Products Inc. (US) | 2001-05-16 | — | — | EP | disclosed |
| US-6121283-A | Apo B-secretion/MTP inhibitory amides | PFIZER INC (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0944602-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023593-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1998-06-04 | — | — | WO | disclosed |