⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20799597 | 0.81 | HRH3 (0.31) | — | |
| SCHEMBL24866097 | 0.81 | HRH3 (0.31) | — | |
| SCHEMBL2271063 | 0.75 | CHRNA7 (0.33) | — | |
| SCHEMBL23267575 | 0.75 | CHRNA7 (0.33) | — | |
| SCHEMBL13849461 | 0.75 | CHRNA7 (0.33) | — | |
| SCHEMBL16538590 | 0.71 | ALDH1A1 (0.40) | — | |
| SCHEMBL1005825 | 0.71 | HSD11B1 (0.31) | — | |
| SCHEMBL16882865 | 0.69 | — | — | |
| SCHEMBL23265467 | 0.69 | — | — | |
| SCHEMBL21850190 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102727498-A | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha | EXELIXIS INC LAMB PETER MATTHEWS DAVID | 2012-10-17 | — | — | CN | claimed |
| CN-101959516-A | Combination therapy comprising quinoxaline PI3K alpha inhibitors for the treatment of cancer | EXELIXIS INC | 2011-01-26 | — | — | CN | claimed |
| CN-101715345-A | Methods of treatment using pyridopyrimidinone PI3K alpha inhibitors | EXELIXIS INC | 2010-05-26 | — | — | CN | claimed |
| US-20030176445-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. | 2003-09-18 | — | — | US | claimed |
| EP-1106615-B1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |
| US-20020042421-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | OKUMURA YOSHIYUKI (JP) | 2002-04-11 | — | — | US | claimed |
| EP-1106615-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | claimed |
| US-10507209-B2 | Quinazoline derivatives substituted by aniline, preparation method and use thereof | XUANZHU PHARMA CO, LTD. (CN) | 2019-12-17 | — | — | US | disclosed |
| US-9956222-B2 | Quinazoline derivative as tyrosine-kinase inhibitor, preparation method therefor and application thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2018-05-01 | — | — | US | disclosed |
| EP-2738156-B1 | 9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUNDS | KBP BIOSCIENCES USA INC (US) | 2018-01-03 | — | — | EP | disclosed |
| US-20170333433-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO, LTD. (CN) | 2017-11-23 | — | — | US | disclosed |
| US-20170304305-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-10-26 | — | — | US | disclosed |
| US-9730934-B2 | Quinazoline derivatives substituted by aniline, preparation method and use thereof | Xuanzhu Pharma Co., Ltd. (CN) | 2017-08-15 | — | — | US | disclosed |
| CN-102727498-A | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha | EXELIXIS INC LAMB PETER MATTHEWS DAVID | 2012-10-17 | — | — | CN | disclosed |
| CN-101959516-A | Combination therapy comprising quinoxaline PI3K alpha inhibitors for the treatment of cancer | EXELIXIS INC | 2011-01-26 | — | — | CN | disclosed |
| CN-101715345-A | Methods of treatment using pyridopyrimidinone PI3K alpha inhibitors | EXELIXIS INC | 2010-05-26 | — | — | CN | disclosed |
| US-20030176445-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. | 2003-09-18 | — | — | US | disclosed |
| EP-1106615-B1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| US-20020042421-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | OKUMURA YOSHIYUKI (JP) | 2002-04-11 | — | — | US | disclosed |
| EP-1106615-A1 | Substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |