Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815238 | 0.92 | GABRA2 (0.49) | GABRA2GABRB2MAPTNPC1NFKB1 | |
| SCHEMBL6971455 | 0.86 | GABRA2 (0.38) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL6974157 | 0.75 | GABRA2 (0.52) | GABRA2GABRB2MAPTNPC1NFKB1 | |
| SCHEMBL6974502 | 0.73 | GABRA2 (0.45) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL7815528 | 0.72 | GABRA2 (0.47) | GABRA2GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL27477232 | 0.72 | GABRA2 (0.49) | GABRA2GABRB2MAPTNPC1NFKB1 | |
| SCHEMBL6553904 | 0.69 | GABRA2 (0.44) | GABRA2GABRB2SMN1; SMN2GABRPGABRD | |
| SCHEMBL6959168 | 0.68 | GABRA2 (0.45) | GABRA2GABRB2MAPTNPC1NFKB1 | |
| SCHEMBL15452465 | 0.67 | PTGS2 (0.71) | MAPTSMN1; SMN2MEN1HPGDKMT2A | |
| SCHEMBL8444622 | 0.66 | GABRA2 (0.52) | GABRA2GABRB2MAPTNPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946515-B1 | PARASITICIDAL PYRAZOLES | PFIZER LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6268509-B1 | PESTICIDES | PFIZER INC | 2001-07-31 | — | — | US | disclosed |
| US-6075043-A | Parasiticidal pyrazoles | PFIZER INC. (US) | 2000-06-13 | — | — | US | disclosed |