Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29744481 | 0.84 | CA12 (1.00) | CA12CA9ALDH1A1KMT2AMAPT | |
| SCHEMBL522649 | 0.84 | CA12 (1.00) | CA12CA9ALDH1A1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7085111 | 0.82 | CA12 (0.96) | CA12CA9ALDH1A1KMT2AMAPT | |
| Phosphine SCHEMBL31113454 | 0.82 | CA12 (0.96) | CA12CA9ALDH1A1KMT2AMAPT | |
| SCHEMBL7133295 | 0.79 | KMT2A (0.60) | CA12CA9ALDH1A1KMT2AMAPT | |
| SCHEMBL2604740 | 0.78 | CA12 (0.58) | CA12CA9ALDH1A1KMT2AMEN1 | |
| SCHEMBL8143584 | 0.76 | KMT2A (0.76) | CA12CA9ALDH1A1KMT2AMAPT | |
| Phthalic Acid SCHEMBL30666341 | 0.76 | CA12 (0.82) | CA12CA9ALDH1A1KMT2AMAPT | |
| SCHEMBL8151455 | 0.73 | MAPT (0.56) | CA12CA9ALDH1A1KMT2AMAPT | |
| SCHEMBL8136034 | 0.72 | CA12 (0.55) | CA12CA9ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718289-B1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-5681843-A | ANTIDIABETIC; ALDOSE REDUCTASE INHIBITOR WITHOUT SUBSTANTIALLY INHIBITING ALDEHYDE REDUCATASE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0718289-A1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |