Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.58 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11453331 | 0.87 | ALDH1A1 (0.77) | KMT2AALDH1A1PIN1PIN4MAPT | |
| SCHEMBL6974847 | 0.79 | CA12 (0.71) | KMT2AALDH1A1MAPTHSD17B10MEN1 | |
| SCHEMBL9323818 | 0.79 | KMT2A (0.76) | KMT2AALDH1A1MAPTMEN1ATM | |
| SCHEMBL9325801 | 0.77 | KMT2A (0.62) | KMT2APIN1PIN4MAPTMEN1 | |
| SCHEMBL9325767 | 0.77 | KMT2A (0.77) | KMT2AALDH1A1PIN1PIN4MAPT | |
| SCHEMBL1989875 | 0.77 | ALDH1A1 (0.61) | KMT2AALDH1A1PIN1PIN4MAPT | |
| SCHEMBL9324908 | 0.76 | KMT2A (0.72) | KMT2AALDH1A1PIN1PIN4MAPT | |
| SCHEMBL523639 | 0.75 | PIN1 (0.68) | KMT2AALDH1A1PIN1PIN4MAPT | |
| SCHEMBL9798486 | 0.75 | HPGD (0.63) | KMT2AALDH1A1PIN1PIN4MAPT | |
| SCHEMBL9323903 | 0.75 | KMT2A (0.59) | KMT2APIN1PIN4MEN1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718289-B1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2003-03-05 | — | — | EP | disclosed |
| US-5681843-A | ANTIDIABETIC; ALDOSE REDUCTASE INHIBITOR WITHOUT SUBSTANTIALLY INHIBITING ALDEHYDE REDUCATASE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0718289-A1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |