Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439829 | 0.91 | HPGD (0.54) | HPGDLMNAGAAFFAR1NPSR1 | |
| SCHEMBL6976203 | 0.77 | HDAC3 (0.48) | LMNAFFAR1HTTALDH1A1TDP1 | |
| SCHEMBL4918761 | 0.76 | CYP2C19 (0.47) | HPGDLMNAGAAFFAR1NPSR1 | |
| SCHEMBL6097252 | 0.75 | LMNA (0.45) | HPGDLMNAGAAFFAR1NPSR1 | |
| SCHEMBL68253 | 0.75 | FFAR1 (0.58) | HPGDLMNAGAAFFAR1NPSR1 | |
| SCHEMBL28246645 | 0.75 | POLB (0.49) | LMNAMEN1KMT2AHTTCYP1A2 | |
| Acetamide SCHEMBL20475067 | 0.75 | NOS3 (0.48) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL108988 | 0.74 | ESR1 (0.48) | LMNAMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL109205 | 0.73 | LMNA (0.53) | HPGDLMNAMEN1KMT2ACYP2D6 | |
| SCHEMBL8109949 | 0.73 | CACNA1B (0.50) | HPGDLMNAGAACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339694-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002040453-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-23 | — | — | WO | disclosed |