Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969926 | 0.90 | TP53 (0.36) | TOP2ATOP2B | |
| SCHEMBL6973990 | 0.88 | MEN1 (0.34) | SMN1; SMN2 | |
| SCHEMBL7084899 | 0.88 | TOP2A (0.32) | KDM4EAPOBEC3ASMN1; SMN2APOBEC3GTOP2A | |
| SCHEMBL7083502 | 0.87 | KDM4E (0.33) | KDM4EAPOBEC3ASMN1; SMN2APOBEC3GTOP2A | |
| SCHEMBL6972382 | 0.87 | HSP90B1 (0.30) | HSP90B1 | |
| SCHEMBL6962712 | 0.87 | — | — | |
| SCHEMBL6961025 | 0.87 | LMNA (0.36) | SMN1; SMN2HSP90B1 | |
| SCHEMBL6973270 | 0.85 | TOP2A (0.46) | KDM4EAPOBEC3ASMN1; SMN2APOBEC3GTOP2A | |
| SCHEMBL6965682 | 0.83 | TSHR (0.35) | SMN1; SMN2HSP90B1 | |
| SCHEMBL6961504 | 0.83 | ENPP2 (0.35) | KDM4ETOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |