Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPTLC2 | O15270 | 4/20 | 1.00 |
| ▸ | SPTLC3 | Q9NUV7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981735 | 0.94 | SPTLC2 (0.89) | SPTLC2SPTLC3KDM4EPDE4APDE4B | |
| SCHEMBL6981749 | 0.92 | SPTLC2 (0.85) | SPTLC2SPTLC3KDM4ETP53PDE4A | |
| SCHEMBL6968663 | 0.91 | SPTLC2 (0.84) | SPTLC2SPTLC3KDM4ETP53PDE4A | |
| SCHEMBL6982993 | 0.87 | SPTLC2 (0.77) | SPTLC2SPTLC3KDM4EPDE4APDE4B | |
| SCHEMBL6983112 | 0.87 | SPTLC2 (0.76) | SPTLC2SPTLC3KDM4ETP53PDE4A | |
| Hydrochloric Acid SCHEMBL6975644 | 0.86 | SPTLC2 (0.75) | SPTLC2SPTLC3KDM4EPDE4APDE4B | |
| SCHEMBL6981585 | 0.86 | SPTLC2 (0.75) | SPTLC2SPTLC3KDM4EPDE4APDE4B | |
| SCHEMBL19892939 | 0.84 | SPTLC2 (0.76) | SPTLC2SPTLC3KDM4ETP53PDE4A | |
| SCHEMBL19893042 | 0.84 | SPTLC2 (0.82) | SPTLC2SPTLC3KDM4EPDE4APDE4B | |
| SCHEMBL6973987 | 0.83 | SPTLC2 (0.71) | SPTLC2SPTLC3KDM4ETP53PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030216398-A1 | Soluble beta amyloid precursor protein secretion promoters | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 2003-11-20 | — | — | US | disclosed |
| EP-1283055-A1 | SOLUBLE BETA AMYLOID PRECURSOR PROTEIN SECRETION PROMOTERS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216398-A1 | Soluble beta amyloid precursor protein secretion promoters | APP, BDNF, BACE1 | SPTLC2 3161/4885SPTLC3 3614/4885KDM4E 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.