SCHEMBL6975291

SCHEMBL6975291

Cc1c(CCCC(=O)O)c[nH]c(=O)c1[N+](=O)[O-]

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
F13A1 P00488 3/20 0.36
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KDM4E B2RXH2 1/20 0.35
PDGFRB P09619 1/20 0.34
FGFR1 P11362 1/20 0.34
KDR P35968 1/20 0.34
ZAP70 P43403 1/20 0.34
IMPDH2 P12268 1/20 0.34
FBP1 P09467 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.33
ALDH1A1 P00352 1/20 0.33
ATM Q13315 1/20 0.33
MMP14 P50281 1/20 0.33
THRB P10828 1/20 0.33
HPGD P15428 1/20 0.33
NQO2 P16083 1/20 0.33
MTNR1A P48039 1/20 0.33
MTNR1B P49286 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6968540 0.92 PDGFRB (0.40) KMT2ASMN1; SMN2KDM4EPDGFRBFGFR1
SCHEMBL6980193 0.83 KDM4E (0.38) KMT2ASMN1; SMN2KDM4EL3MBTL1ALDH1A1
SCHEMBL6969608 0.78 PARP1 (0.43) F13A1KMT2ASMN1; SMN2FBP1L3MBTL1
SCHEMBL2492917 0.77 ALDH1A1 (0.41) F13A1KMT2ASMN1; SMN2IMPDH2ALDH1A1
SCHEMBL20095880 0.71 NPSR1 (0.49) F13A1KMT2ASMN1; SMN2HPGD
SCHEMBL2491279 0.70 NPSR1 (0.47) IMPDH2FBP1ALDH1A1
SCHEMBL722679 0.68 KDM4E (0.55) KMT2ASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL4659158 0.68 CYSLTR2 (0.46) KMT2ASMN1; SMN2ALDH1A1
SCHEMBL30159484 0.68 FFAR4 (0.41) FBP1
SCHEMBL7598825 0.67 F13A1 (0.44) F13A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1272487-A1 BICYCLIC HETEROARYL COMPOUNDS AS INHIBITORS OF THE INTERACTION BETWEEN THE INTEGRIN ALPHA4BETA1 RECEPTOR AND VCAM-1 AND/OR FIBRONECTIN AstraZeneca AB (SE) 2003-01-08 EP disclosed
WO-2001053295-A1 BICYCLIC HETEROARYL COMPOUNDS AS INHIBITORS OF THE INTERACTION BETWEEN THE INTEGRIN ALPHA4BETA1 RECEPTOR AND VCAM-1 AND/OR FIBRONECTIN ASTRAZENECA AB (SE) 2001-07-26 WO disclosed