Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.53 |
| ▸ | ABAT | P80404 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975312 | 1.00 | MAPT (0.54) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL16702025 | 0.87 | ABCC1 (0.51) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL16702023 | 0.87 | ABCC1 (0.51) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL27761089 | 0.85 | MAPK1 (0.54) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL3801985 | 0.85 | HTT (0.68) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL4341820 | 0.84 | MAPT (0.72) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL11194941 | 0.83 | AURKB (0.62) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL2312502 | 0.83 | KMT2A (0.75) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL2312499 | 0.83 | KMT2A (0.75) | MAPTMAPK1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL7213151 | 0.82 | ALDH1A1 (0.56) | MAPTMAPK1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4305040-A1 | TRICYCLIC PYRIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2024-01-17 | — | — | EP | disclosed |
| EP-1106608-B1 | Substituted (dihydro)benzoxazine and (dihydro)benzothiazine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-05 | — | — | EP | disclosed |
| EP-1106608-A1 | Substituted (dihydro)benzoxazine and (dihydro)benzothiazine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-06-13 | — | — | EP | disclosed |