Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976820 | 0.90 | CYP1A2 (0.40) | KCNH2MCHR1CYP1A2LTA4HCYP2D6 | |
| SCHEMBL6980438 | 0.90 | MAPT (0.38) | KCNH2MCHR1LTA4HMAOBMAPT | |
| SCHEMBL6977278 | 0.89 | KCNH2 (0.45) | KCNH2MCHR1CYP1A2LTA4HCYP2D6 | |
| SCHEMBL7085291 | 0.85 | MAPT (0.37) | KCNH2MCHR1MAOBMAPTRAB9A | |
| SCHEMBL8483767 | 0.85 | PSEN1 (0.40) | MAPTPSEN1MEN1KMT2ATDP1 | |
| SCHEMBL6980211 | 0.85 | PSEN1 (0.38) | MAPTPSEN1MEN1KMT2ATDP1 | |
| SCHEMBL6969686 | 0.85 | PSEN1 (0.40) | MAPTPSEN1MEN1KMT2ATDP1 | |
| SCHEMBL6977672 | 0.85 | PPARG (0.40) | KCNH2MCHR1CYP1A2LTA4HCYP2D6 | |
| SCHEMBL6974454 | 0.84 | HPGD (0.49) | MAOBMAOAMEN1KMT2APPARG | |
| SCHEMBL6974450 | 0.84 | HPGD (0.49) | MAOBMAOAMEN1KMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |