Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975450 | 0.92 | PPARG (0.41) | PPARGPSEN1ALOX5LTA4HL3MBTL1 | |
| SCHEMBL6979165 | 0.88 | PPARG (0.40) | PPARGPSEN1ALOX5LTA4HL3MBTL1 | |
| SCHEMBL6976820 | 0.85 | CYP1A2 (0.40) | PPARGPSEN1KCNH2MCHR1ALOX5 | |
| SCHEMBL6975335 | 0.85 | KCNH2 (0.39) | PPARGPSEN1KCNH2MCHR1ALOX5 | |
| SCHEMBL6977278 | 0.83 | KCNH2 (0.45) | PPARGPSEN1KCNH2MCHR1CYP1A2 | |
| SCHEMBL6979922 | 0.81 | MEN1 (0.42) | PPARGPSEN1ALOX5MEN1MAPT | |
| SCHEMBL6963536 | 0.81 | PPARG (0.46) | PPARGCYP1A2MEN1MAPTKMT2A | |
| SCHEMBL6969686 | 0.80 | PSEN1 (0.40) | PPARGPSEN1ALOX5MEN1MAPT | |
| SCHEMBL8483767 | 0.80 | PSEN1 (0.40) | PPARGPSEN1ALOX5MEN1MAPT | |
| SCHEMBL6974450 | 0.79 | HPGD (0.49) | PPARGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |