SCHEMBL6975605

SCHEMBL6975605

N#CCCCC(c1ccccc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 6/20 0.56
HTR2A P28223 6/20 0.56
SIGMAR1 Q99720 3/20 0.47
TRPA1 O75762 1/20 0.41
TSHR P16473 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
CYP19A1 P11511 3/20 0.41
KCNH2 Q12809 1/20 0.40
GRM2 Q14416 1/20 0.40
GRM3 Q14832 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4755511 0.88 HRH1 (0.50) HRH1HTR2ASIGMAR1TRPA1TSHR
SCHEMBL11378052 0.83 RIPK1 (0.50) TSHR
SCHEMBL9702595 0.81 ESR1 (0.47) HRH1HTR2ATSHRTAAR1CYP19A1
SCHEMBL31163414 0.81 SCN4A (0.41) HRH1HTR2ATRPA1TSHRTAAR1
SCHEMBL29756126 0.81 TRPA1 (0.47) HRH1HTR2ASIGMAR1TRPA1TSHR
SCHEMBL14387186 0.81 RIPK1 (0.50) TRPA1TAAR1
SCHEMBL2161771 0.81 RIPK1 (0.50) TRPA1TAAR1
SCHEMBL10451727 0.81 CCR1 (0.43) HRH1HTR2ATRPA1TSHR
SCHEMBL9073997 0.80 HRH1 (0.71) HRH1HTR2ASIGMAR1TAAR1CYP19A1
SCHEMBL5329154 0.77 CYP2C19 (0.47) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
EP-0923575-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS Takeda Chemical Industries, Ltd. (JP) 1999-06-23 EP disclosed
WO-1998008842-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-05 WO disclosed