Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16298728 | 0.82 | TERT (0.55) | TERTHSD17B10IP6K1IP6K3MAPT | |
| SCHEMBL21524689 | 0.79 | STAT3 (0.53) | MAPTMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL23775859 | 0.76 | KDM4E (0.45) | HSD17B10MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL26438900 | 0.76 | PARP1 (0.49) | HSD17B10MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL26451280 | 0.75 | KDM4E (0.44) | HSD17B10MAPTKDM4EPARP14PARG | |
| SCHEMBL6985209 | 0.72 | KDM4E (0.42) | HSD17B10IP6K1MAPTALDH1A1KDM4E | |
| SCHEMBL20509747 | 0.71 | KDM4E (0.59) | HSD17B10IP6K1IP6K3MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL28023691 | 0.71 | TUBB4A (0.53) | HSD17B10MAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL2614349 | 0.70 | KDM4E (0.62) | MAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL19521610 | 0.69 | KDM4E (0.40) | HSD17B10MAPTALDH1A1KDM4EPARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183276-B2 | Therapeutic agents | MERCK SHARP & DOHME CORP. | 2012-05-22 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | TERT 1121/4885HSD17B10 1886/4885IP6K1 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.