Sugi Predict

Sugi Predict / Compounds / SCHEMBL697652

SCHEMBL697652

SCHEMBL697652

Cc1cccc([C@H](C)c2nccn2Cc2cc(C(F)(F)F)ccc2Cl)c1C

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 6/20 0.40
▸ P2RX7 Q99572 1/20 0.39
▸ CYP2D6 P10635 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ HIF1A Q16665 1/20 0.37
▸ BRD4 O60885 1/20 0.34
▸ FPR2 P25090 2/20 0.34
▸ ADRA2C P18825 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ TRAP1 Q12931 2/20 0.33
▸ MCL1 Q07820 1/20 0.33
▸ SLC6A2 P23975 1/20 0.33
▸ SLC6A4 P31645 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697925 0.86 CYP2D6 (0.47) KCNH2P2RX7CYP2D6TSHRCYP2C19
SCHEMBL703605 0.85 TDP1 (0.41) KCNH2P2RX7FPR2KMT2ALMNA
SCHEMBL696014 0.85 TDP1 (0.41) KCNH2P2RX7FPR2KMT2ALMNA
SCHEMBL697239 0.83 MAPT (0.46) KCNH2P2RX7MEN1KMT2ALMNA
SCHEMBL696426 0.81 CYP2D6 (0.45) KCNH2P2RX7CYP2D6TSHRCYP2C19
SCHEMBL697472 0.80 ADRA2C (0.41) KCNH2P2RX7ADRA2CKMT2ATP53
SCHEMBL697196 0.80 ADRA2C (0.39) KCNH2P2RX7CYP2D6TSHRCYP2C19
SCHEMBL696351 0.79 CYP2D6 (0.45) KCNH2P2RX7CYP2D6TSHRCYP2C19
SCHEMBL697360 0.79 FSCN1 (0.44) KCNH2BRD4LMNA
SCHEMBL698285 0.79 P2RX7 (0.42) KCNH2P2RX7CYP2D6TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885P2RX7 671/4885CYP2D6 15/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885P2RX7 671/4885CYP2D6 15/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885P2RX7 671/4885CYP2D6 15/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 KCNH2 277/4885P2RX7 671/4885CYP2D6 15/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.