Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27544390 | 0.82 | POLB (0.55) | KMT2AMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL9694189 | 0.79 | KMT2A (0.50) | KMT2AMAPTSMN1; SMN2HSD17B10USP2 | |
| SCHEMBL16744344 | 0.79 | KMT2A (0.65) | KMT2AMAPTHSD17B10LMNAALDH1A1 | |
| SCHEMBL1918507 | 0.78 | KMT2A (0.71) | KMT2AMAPTSMN1; SMN2ESR1ESR2 | |
| SCHEMBL28822923 | 0.77 | KMT2A (0.69) | KMT2AMAPTSMN1; SMN2ESR1ESR2 | |
| SCHEMBL28488504 | 0.76 | KMT2A (0.48) | KMT2AMAPTSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL9480342 | 0.75 | LMNA (0.46) | KMT2AMAPTSMN1; SMN2ESR1ESR2 | |
| SCHEMBL1221234 | 0.75 | LMNA (0.57) | KMT2AMAPTSMN1; SMN2ESR1ESR2 | |
| SCHEMBL28278268 | 0.75 | KDM4E (0.33) | KMT2AMAPTSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL27821892 | 0.74 | MAPT (0.69) | KMT2AMAPTSMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |