Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567956 | 0.81 | KMT2A (0.58) | LMNAKMT2AMAPTSMN1; SMN2METAP2 | |
| SCHEMBL28488504 | 0.78 | KMT2A (0.48) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9099922 | 0.77 | KMT2A (0.43) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9694189 | 0.77 | KMT2A (0.50) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6976790 | 0.75 | KMT2A (0.51) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL11443998 | 0.75 | SLC6A3 (0.60) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL27544390 | 0.74 | POLB (0.55) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8917839 | 0.73 | SMN1; SMN2 (0.47) | KMT2AMAPTSMN1; SMN2SLC6A3HSD17B10 | |
| SCHEMBL27821892 | 0.72 | MAPT (0.69) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL28794462 | 0.72 | ESR1 (0.61) | LMNAKMT2AMAPTSMN1; SMN2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247381-B1 | 5-FLUROROURACIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5047521-A | Anticarcinogenic agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0247381-A2 | 5-flurorouracil derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-12-02 | — | — | EP | disclosed |