SCHEMBL6977025

SCHEMBL6977025

Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCCC1COc1ccc(C=C3SC(=O)NC3=O)cc1)O2

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HPGD P15428 16/20 0.44
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
PARP1 P09874 1/20 0.41
PIM1 P11309 1/20 0.39
PIM2 Q9P1W9 1/20 0.39
HRH3 Q9Y5N1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17289311 1.00 HPGD (0.44) HPGDMEN1MAPTKMT2ATDP1
SCHEMBL6974812 1.00 HPGD (0.44) HPGDMEN1MAPTKMT2ATDP1
SCHEMBL6970058 1.00 HPGD (0.44) HPGDMEN1MAPTKMT2ATDP1
SCHEMBL6975305 0.87 HPGD (0.47) HPGDMEN1KMT2A
SCHEMBL6970447 0.87 HPGD (0.47) HPGDMEN1KMT2A
SCHEMBL6975793 0.87 HPGD (0.47) HPGDMEN1KMT2A
SCHEMBL6975790 0.87 HPGD (0.47) HPGDMEN1KMT2A
SCHEMBL6962895 0.83 MAPT (0.47) HPGDMEN1MAPTKMT2ATDP1
SCHEMBL6966713 0.83 MAPT (0.47) HPGDMEN1MAPTKMT2ATDP1
SCHEMBL6969023 0.83 MAPT (0.47) HPGDMEN1MAPTKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210227822-A1 COMPOUNDS FOR PROTECTION OF CELLS SULFATEQ B.V. (NL) 2021-07-29 US disclosed
US-11006626-B2 Compounds for protection of cells SULFATEQ B.V. (NL) 2021-05-18 US disclosed
US-20190098890-A1 COMPOUNDS FOR PROTECTION OF CELLS SULFATEQ B.V. (NL) 2019-04-04 US disclosed
US-10123529-B2 Compounds for protection of cells SULFATEQ B.V. (NL) 2018-11-13 US disclosed
EP-3388426-A2 COMPOUNDS FOR PROTECTION OF CELLS Sulfateq B.V. (NL) 2018-10-17 EP disclosed
EP-2935232-B1 COMPOUNDS FOR PROTECTION OF CELLS SULFATEQ BV (NL) 2018-06-13 EP disclosed
US-20150342174-A1 COMPOUNDS FOR PROTECTION OF CELLS SULFATEQ B.V. (NL) 2015-12-03 US disclosed
EP-0894089-B9 NOVEL HETEROCYCLIC COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM REDDYS LAB LTD DR (IN) 2003-04-02 EP disclosed
EP-0894089-B1 NOVEL HETEROCYCLIC COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM REDDYS LAB LTD DR (IN) 2002-10-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11006626-B2 Compounds for protection of cells CASP10, BAX, CASP9 HPGD 1301/4885MEN1 1227/4885MAPT 4696/4885
US-20190098890-A1 COMPOUNDS FOR PROTECTION OF CELLS CASP10, BAX, CASP9 HPGD 1301/4885MEN1 1227/4885MAPT 4696/4885
US-20210227822-A1 COMPOUNDS FOR PROTECTION OF CELLS CASP10, BAX, CASP9 HPGD 1301/4885MEN1 1227/4885MAPT 4696/4885
US-10123529-B2 Compounds for protection of cells CASP10, BAX, CASP9 HPGD 1301/4885MEN1 1227/4885MAPT 4696/4885
US-20150342174-A1 COMPOUNDS FOR PROTECTION OF CELLS CASP10, BAX, CASP9 HPGD 1301/4885MEN1 1227/4885MAPT 4696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.