CASP10 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2038060	0.63	4/20
SCHEMBL3317466	0.62	4/20
SCHEMBL7882808	0.75	3/20
SCHEMBL3490826	0.73	3/20
SCHEMBL7878192	0.68	3/20
SCHEMBL3719465	0.66	3/20
SCHEMBL7879243	0.63	3/20
SCHEMBL7879125	0.63	3/20
SCHEMBL6657994	0.63	3/20
SCHEMBL7882800	0.59	3/20
SCHEMBL5697520	0.57	3/20
SCHEMBL4420464	0.56	3/20
SCHEMBL7383742	0.56	3/20
SCHEMBL2039051	0.56	3/20
SCHEMBL4013593	0.55	3/20
SCHEMBL2038936	0.54	3/20
SCHEMBL614741	0.53	3/20
SCHEMBL3140616	0.53	3/20
SCHEMBL2744395	0.53	3/20
SCHEMBL7420154	0.52	3/20

Clinical trials — most relevant to CASP10 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Minocycline for the Treatment of Early-Phase Schizophrenia	PHASE3	COMPLETED
Study About Efficacy and Safety to Treat Multi-System-Atrophy	PHASE3	COMPLETED
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery	PHASE1/PHASE2	UNKNOWN
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Remote Ischemic Preconditioning of Human Myocardium	PHASE2	COMPLETED
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.	nan	UNKNOWN
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Study of CRP, Ferritine and D-Dimer in Covid-19 Patients Admitted To Respiratory ICU in Assuit University Hospitals	nan	UNKNOWN
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient	nan	RECRUITING
Exercise and the Receptor for Advanced Glycation End Products (RAGE)	nan	COMPLETED
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients	nan	RECRUITING
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
Genetics of the Early and Late Response to Allergen Challenge	nan	COMPLETED
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Mechanisms Relating to the Distinct in Vitro Susceptibility of Human Macrophages to L. Viannia Infection	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CASP10 binder may also engage these)

Protein	Name	Similarity
O35732	—	0.990	O35732 →
Q9JHX4	—	0.985	Q9JHX4 →
Q0P5I2	—	0.977	Q0P5I2 →
D4A7V9	—	0.976	D4A7V9 →
Q9QZ05	—	0.976	Q9QZ05 →
Q5RCZ8	—	0.975	Q5RCZ8 →
Q3US16	—	0.975	Q3US16 →
O08727	—	0.974	O08727 →
Q9R016	—	0.974	Q9R016 →
A0A386CAB9	—	0.973	A0A386CAB9 →
A5D7R1	—	0.973	A5D7R1 →
Q4QQS0	—	0.973	Q4QQS0 →
CASP9	Caspase-9	0.973	landscape →
P55215	—	0.972	P55215 →
Q9H930	—	0.972	Q9H930 →
Q2IBB1	—	0.972	Q2IBB1 →
Q07DZ7	—	0.972	Q07DZ7 →
Q07E17	—	0.972	Q07E17 →
Q8K4I3	—	0.972	Q8K4I3 →
Q09YK6	—	0.972	Q09YK6 →
Q8BHB0	—	0.971	Q8BHB0 →
Q9Y2G2	—	0.971	Q9Y2G2 →
Q13075	—	0.971	Q13075 →
Q9NRM6	—	0.971	Q9NRM6 →
Q6NVF4	—	0.971	Q6NVF4 →
PARP14	Protein mono-ADP-ribosyltransferase PARP14	0.971	landscape →
Q8R5F7	—	0.970	Q8R5F7 →
Q9NXL2	—	0.970	Q9NXL2 →
Q9D684	—	0.970	Q9D684 →
Q5M7P8	—	0.970	Q5M7P8 →