Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655752 | 0.85 | TAAR1 (0.76) | MEN1KMT2AL3MBTL1SIGMAR1TAAR1 | |
| SCHEMBL21677 | 0.81 | MEN1 (0.95) | MEN1KMT2AL3MBTL1SIGMAR1TAAR1 | |
| SCHEMBL4592122 | 0.80 | TAAR1 (0.68) | MEN1KMT2AL3MBTL1HTR2ASIGMAR1 | |
| SCHEMBL6849740 | 0.79 | TAAR1 (0.73) | MEN1KMT2AL3MBTL1SIGMAR1TAAR1 | |
| SCHEMBL22331586 | 0.79 | MEN1 (0.84) | MEN1KMT2AL3MBTL1SIGMAR1TAAR1 | |
| Hydrochloric Acid SCHEMBL6552954 | 0.79 | MEN1 (1.00) | MEN1KMT2AL3MBTL1SIGMAR1TAAR1 | |
| Propane SCHEMBL8097570 | 0.77 | MEN1 (0.88) | MEN1KMT2AL3MBTL1SIGMAR1TAAR1 | |
| SCHEMBL680531 | 0.75 | L3MBTL1 (1.00) | MEN1KMT2AL3MBTL1SIGMAR1TAAR1 | |
| Phenethylamine SCHEMBL4688766 | 0.75 | TAAR1 (0.80) | L3MBTL1HTR2ATAAR1SMN1; SMN2CYP2A6 | |
| SCHEMBL10812127 | 0.75 | HTR2A (0.60) | MEN1KMT2AHTR2ASIGMAR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218343-A4 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2003-06-18 | — | — | EP | disclosed |
| EP-1218343-A1 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001025203-A1 | PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-04-12 | — | — | WO | disclosed |