Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17394819 | 0.89 | POLB (0.56) | NPC1RAB9AEPHB4GAAPTK2 | |
| SCHEMBL13955883 | 0.82 | IGF1R (0.59) | EPHB4EGFRJAK2CDK2PIK3CA | |
| SCHEMBL13325996 | 0.81 | PTK2 (0.62) | EPHB4EGFRJAK2CDK2PIK3CA | |
| SCHEMBL1131578 | 0.78 | CDK2 (0.68) | EPHB4EGFRJAK2CDK2PIK3CA | |
| SCHEMBL15398857 | 0.76 | PTK2 (0.60) | EPHB4EGFRJAK2CDK2PIK3CA | |
| SCHEMBL14088802 | 0.76 | IGF1R (0.62) | EPHB4EGFRJAK2CDK2PIK3CA | |
| SCHEMBL16677957 | 0.76 | IGF1R (0.56) | EPHB4EGFRCDK2MEN1KMT2A | |
| SCHEMBL6979383 | 0.74 | BRAF (0.60) | PTK2POLBMEN1CYP1A2MAPT | |
| SCHEMBL19654192 | 0.74 | KDR (0.55) | EPHB4EGFRJAK2CDK2PIK3CA | |
| SCHEMBL3407955 | 0.73 | NPC1 (0.51) | NPC1RAB9AEPHB4GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |