Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 4/20 | 0.93 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182258 | 0.96 | LSS (1.00) | LSSNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL8310078 | 0.95 | LSS (0.83) | LSSNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL6977537 | 0.93 | LSS (0.93) | LSSNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL6980932 | 0.91 | LSS (0.77) | LSSNPC1RAB9AALDH1A1NPSR1 | |
| SCHEMBL8309729 | 0.91 | LSS (0.89) | LSSNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL6978604 | 0.88 | LSS (0.71) | LSSALDH1A1L3MBTL1 | |
| SCHEMBL6975859 | 0.87 | LSS (0.71) | LSSNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL6977459 | 0.85 | LSS (0.93) | LSSNPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL6980904 | 0.84 | LSS (0.68) | LSSNPC1RAB9AALDH1A1TSHR | |
| SCHEMBL6977387 | 0.83 | LSS (0.76) | LSSALDH1A1L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |