Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 11/20 | 0.41 |
| ▸ | PLG | P00747 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436546 | 0.86 | PLAU (0.51) | PLAUPLGKMT2APLATMEN1 | |
| SCHEMBL6439004 | 0.83 | PLAU (0.46) | PLAUPLGPLATKDM4C | |
| SCHEMBL6433372 | 0.81 | PLAU (0.44) | PLAUPLGALDH1A1PLAT | |
| SCHEMBL6437774 | 0.74 | PLAU (0.72) | PLAUPLGPLAT | |
| Hydrochloric Acid SCHEMBL6438812 | 0.73 | PLAU (0.71) | PLAUPLGPLAT | |
| SCHEMBL7386231 | 0.73 | PLAU (0.53) | PLAUPLGKMT2APLATMEN1 | |
| Hydrochloric Acid SCHEMBL6433490 | 0.73 | PLAU (0.70) | PLAUPLGMAPK1PLAT | |
| Bicarbonate SCHEMBL6969353 | 0.72 | PLAU (0.63) | PLAUPLGMAPK1ALDH1A1PLAT | |
| Hydrochloric Acid SCHEMBL6435316 | 0.72 | PLAU (0.56) | PLAUPLGPLAT | |
| Bicarbonate SCHEMBL6964761 | 0.71 | PLAU (0.64) | PLAUPLGMAPK1ALDH1A1PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER (US) | 2003-01-08 | — | — | EP | claimed |