Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | NPEPPS | P55786 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.54 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974482 | 0.87 | KDM4E (0.78) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL6981446 | 0.86 | KDM4E (0.71) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL6971771 | 0.85 | HTT (0.72) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL6980347 | 0.84 | KDM4E (1.00) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL6283505 | 0.84 | PDE7A (0.77) | KDM4EGAATP53HTTNPC1 | |
| SCHEMBL2762691 | 0.84 | KDM4E (0.54) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL2762692 | 0.84 | BRD4 (0.56) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL6970729 | 0.84 | GAA (0.64) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL6973874 | 0.84 | TP53 (0.62) | KDM4EGAATP53HTTSMN1; SMN2 | |
| SCHEMBL12889780 | 0.84 | TP53 (0.62) | KDM4EGAATP53HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030199530-A1 | New compounds derived from quinazoline | LES LABORATORIES SERVIER (FR) | 2003-10-23 | — | — | US | disclosed |
| EP-1346992-A1 | Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-09-24 | — | — | EP | disclosed |
| EP-0653423-B1 | Process for the preparation of substituted quinazoline-2,4-diones | CLARIANT GMBH (DE) | 1999-06-16 | — | — | EP | disclosed |
| US-5539114-A | Process for the preparation of substituted quinazoline-2,4,-diones | HOECHST AG (DE) | 1996-07-23 | — | — | US | disclosed |
| EP-0653423-A1 | Process for the preparation of substituted quinazoline-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199530-A1 | New compounds derived from quinazoline | NQO2, XDH, DRD1 | KDM4E 4217/4885GAA 638/4885TP53 3198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.