Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.70 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | NPEPPS | P55786 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.58 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.58 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.58 |
| ▸ | FEN1 | P39748 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971771 | 0.88 | HTT (0.72) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL1548586 | 0.86 | TP53 (0.62) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL6970729 | 0.86 | GAA (0.64) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL6982369 | 0.86 | KDM4E (0.60) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL8217549 | 0.86 | KDM4E (0.60) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL6973874 | 0.86 | TP53 (0.62) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL12889780 | 0.86 | TP53 (0.62) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL6977596 | 0.86 | KDM4E (0.73) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL6983353 | 0.86 | TP53 (0.58) | KDM4EGAAPDE7APDE7BTP53 | |
| SCHEMBL6980347 | 0.84 | KDM4E (1.00) | KDM4EGAAPDE7APDE7BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030199530-A1 | New compounds derived from quinazoline | LES LABORATORIES SERVIER (FR) | 2003-10-23 | — | — | US | disclosed |
| EP-1346992-A1 | Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |
| US-4551458-A | 1-HALOALKYLTHIO DERIVATIVES | MAKHTESHIM CHEMICAL WORKS, LTD. (IL) | 1985-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199530-A1 | New compounds derived from quinazoline | NQO2, XDH, DRD1 | KDM4E 4217/4885GAA 638/4885PDE7A 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.