Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 12/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970869 | 0.86 | ADRA1D (0.54) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| Alcohol SCHEMBL8547581 | 0.84 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| Alcohol SCHEMBL8381334 | 0.84 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL8096185 | 0.82 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL8096179 | 0.82 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL8384932 | 0.81 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL6980379 | 0.81 | ADRA1D (0.55) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL7469835 | 0.79 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL9302003 | 0.79 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL6763070 | 0.76 | ADRA1D (0.76) | ADRA1DADRA1AADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | claimed |
| CN-1071755-C | Heterocyclylcarboxamide derivatives and their use as therapeutic agents | KNOLL AG (DE) | 2001-09-26 | — | — | CN | claimed |
| US-5935973-A | AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS | KNOLL AKTIENGESELLSCHAFT (DE) | 1999-08-10 | — | — | US | claimed |
| CN-1190967-A | Heterocyclylcarboxamide derivatives and their use as therapeutic agents | KNOLL AG (DE) | 1998-08-19 | — | — | CN | claimed |
| EP-0839145-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1998-05-06 | — | — | EP | claimed |
| WO-1997003071-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-30 | — | — | WO | claimed |
| EP-0839145-B1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2003-11-05 | — | — | EP | disclosed |
| CN-1071755-C | Heterocyclylcarboxamide derivatives and their use as therapeutic agents | KNOLL AG (DE) | 2001-09-26 | — | — | CN | disclosed |
| US-5935973-A | AFFINITY FOR 5-HT1A, ALPHA1, ALPHA2 AND/OR D2 RECEPTORS; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, PSYCHOSES, DYSKINESIAS, PARKINSON'S DISEASE, HYPOTENSIVE AGENTS, TOURETTE'S SYNDROME, OBSESSIVE-COMPULSIVE BEHAVIOUR, PANIC ATTACKS, SOCIAL PHOBIAS | KNOLL AKTIENGESELLSCHAFT (DE) | 1999-08-10 | — | — | US | disclosed |
| CN-1190967-A | Heterocyclylcarboxamide derivatives and their use as therapeutic agents | KNOLL AG (DE) | 1998-08-19 | — | — | CN | disclosed |
| EP-0839145-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997003071-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-30 | — | — | WO | disclosed |