Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.68 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637025 | 0.83 | PAX8 (0.64) | F2PAX8POLBLMNAPKM | |
| SCHEMBL8166575 | 0.81 | F2 (1.00) | F2PAX8POLBLMNAPKM | |
| SCHEMBL7667173 | 0.81 | F2 (0.56) | F2LMNAPKMALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8016790 | 0.80 | F2 (0.98) | F2PAX8POLBLMNAPKM | |
| SCHEMBL7243857 | 0.80 | F2 (0.54) | F2ALDH1A1SMN1; SMN2THRBRAB9A | |
| SCHEMBL6977191 | 0.80 | F2 (0.55) | F2PAX8POLBLMNAPKM | |
| SCHEMBL7670672 | 0.77 | F2 (0.73) | F2PAX8POLBLMNAPKM | |
| SCHEMBL6635661 | 0.76 | F2 (0.68) | F2PAX8POLBLMNAPKM | |
| SCHEMBL7670465 | 0.75 | F2 (0.49) | F2PAX8POLBLMNAALDH1A1 | |
| SCHEMBL8027058 | 0.75 | F2 (0.70) | F2PAX8POLBLMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220844-B1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |