Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 0.56 |
| ▸ | F13A1 | P00488 | 6/20 | 0.56 |
| ▸ | TGM1 | P22735 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975890 | 0.86 | NEK2 (0.52) | POLBPKMSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL629912 | 0.85 | MEN1 (0.54) | POLBSMN1; SMN2GAATSHRCYP2C19 | |
| SCHEMBL4235140 | 0.83 | TGM2 (0.67) | TGM2F13A1TGM1POLBPKM | |
| SCHEMBL630859 | 0.81 | MEN1 (0.50) | POLBSMN1; SMN2GAATSHRCYP2C19 | |
| SCHEMBL7261681 | 0.78 | TGM2 (0.45) | TGM2F13A1TGM1POLBPKM | |
| SCHEMBL17277447 | 0.77 | TGM2 (0.69) | TGM2F13A1TGM1POLBPKM | |
| SCHEMBL3971768 | 0.77 | TGM2 (0.69) | TGM2F13A1TGM1POLBPKM | |
| SCHEMBL8394062 | 0.75 | TGM2 (0.65) | TGM2F13A1TGM1POLBPKM | |
| SCHEMBL6938176 | 0.75 | MEN1 (0.56) | POLBSMN1; SMN2GAATSHRCYP2C19 | |
| SCHEMBL29365580 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |