Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 2/20 | 0.50 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977941 | 0.86 | TGM2 (0.56) | ALDH1A1GAAPOLBPKMSMN1; SMN2 | |
| SCHEMBL6980266 | 0.81 | CYP2D6 (0.54) | ALDH1A1GPR183 | |
| SCHEMBL27562279 | 0.78 | KMT2A (0.43) | NEK2FPR2PROKR1ALDH1A1GAA | |
| SCHEMBL16013324 | 0.77 | HSD11B1 (0.62) | ALDH1A1GPR183LMNA | |
| SCHEMBL6520496 | 0.76 | ALDH1A1 (0.58) | ALDH1A1GAACYP2C9POLBPKM | |
| SCHEMBL6948417 | 0.76 | ALDH1A1 (0.81) | ALDH1A1GAAPOLBPKMLMNA | |
| SCHEMBL13548570 | 0.74 | POLB (0.64) | FPR2PROKR1ALDH1A1GAACYP2C9 | |
| SCHEMBL504642 | 0.74 | ALDH1A1 (0.53) | ALDH1A1CYP2C9POLBPKMSMN1; SMN2 | |
| SCHEMBL18065510 | 0.74 | ALDH1A1 (0.48) | ALDH1A1GPR183LMNA | |
| SCHEMBL612745 | 0.73 | ALDH1A1 (0.54) | ALDH1A1MAPTCYP2C9POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| US-6093718-A | AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |