SCHEMBL6978083

SCHEMBL6978083

O=C(Cl)c1snc2ccc([N+](=O)[O-])cc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TXNRD1 Q16881 1/20 0.47
TXNRD3 Q86VQ6 1/20 0.47
TXNRD2 Q9NNW7 1/20 0.47
ALDH1A1 P00352 5/20 0.44
TSHR P16473 2/20 0.43
PARP1 P09874 1/20 0.41
KMT2A Q03164 4/20 0.41
OPRK1 P41145 1/20 0.41
MEN1 O00255 2/20 0.40
POLB P06746 1/20 0.40
PKM P14618 1/20 0.40
NPY1R P25929 1/20 0.40
NPY2R P49146 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ACHE P22303 1/20 0.39
DYRK1A Q13627 1/20 0.39
CYP3A4 P08684 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2964632 0.75 TXNRD1 (0.53) TXNRD1TXNRD3TXNRD2ALDH1A1TSHR
SCHEMBL11920449 0.75 TXNRD1 (0.53) TXNRD1TXNRD3TXNRD2ALDH1A1TSHR
SCHEMBL6770639 0.73 ALDH1A1 (0.44) TXNRD1TXNRD3TXNRD2ALDH1A1TSHR
Nitrogen SCHEMBL27809397 0.73 TXNRD1 (0.50) TXNRD1TXNRD3TXNRD2ALDH1A1TSHR
SCHEMBL10510783 0.72 TXNRD1 (0.49) TXNRD1TXNRD3TXNRD2ALDH1A1TSHR
SCHEMBL8878527 0.71 MAPT (0.56) ALDH1A1TSHRKMT2AMEN1POLB
SCHEMBL7818905 0.69 MAPT (0.44) ALDH1A1KMT2AMEN1POLBHTT
SCHEMBL7815141 0.69 TXNRD1 (0.45) TXNRD1TXNRD3TXNRD2ALDH1A1TSHR
SCHEMBL7817467 0.68 TXNRD1 (0.44) TXNRD1TXNRD3TXNRD2ALDH1A1TSHR
SCHEMBL1448047 0.68 ALDH1A1 (0.67) ALDH1A1TSHRKMT2AMEN1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1274708-A1 HERBICIDAL 3-HETEROCYCLIC SUBSTITUTED BENZISOTHIAZOLE AND BENZISOXAZOLE COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2003-01-15 EP disclosed
WO-2001079203-A1 HERBICIDAL 3-HETEROCYCLIC SUBSTITUTED BENZISOTHIAZOLE AND BENZISOXAZOLE COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2001-10-25 WO disclosed