Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 2/20 | 0.95 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180713 | 0.97 | PSIP1 (1.00) | PSIP1HSD11B1GAAHTR6POLB | |
| Fluoride SCHEMBL9493182 | 0.95 | PSIP1 (0.95) | PSIP1HSD11B1GAAHTR6POLB | |
| Methylamine SCHEMBL28266275 | 0.92 | PSIP1 (0.90) | PSIP1HSD11B1GAAHTR6POLB | |
| SCHEMBL27891797 | 0.90 | PSIP1 (0.86) | PSIP1HSD11B1GAAHTR6POLB | |
| Sulfuric Acid SCHEMBL27681094 | 0.90 | PSIP1 (0.86) | PSIP1HSD11B1GAAHTR6POLB | |
| Acetic Acid SCHEMBL28112958 | 0.88 | PSIP1 (0.82) | PSIP1HSD11B1GAAPOLBALDH1A1 | |
| SCHEMBL789569 | 0.88 | PSIP1 (0.82) | PSIP1HSD11B1GAAHTR6POLB | |
| SCHEMBL14431973 | 0.88 | PSIP1 (0.82) | PSIP1HSD11B1GAAHTR6POLB | |
| Methylphenylsulfone SCHEMBL9733545 | 0.88 | PSIP1 (0.82) | PSIP1HSD11B1GAAPOLBALDH1A1 | |
| Phenol SCHEMBL28291911 | 0.86 | PSIP1 (0.78) | PSIP1HSD11B1GAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |
| EP-1131321-A2 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031074-A2 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-06-02 | — | — | WO | disclosed |